Young knight Antonio learns that Magellan plans to travel to the mysterious Maluku islands of Indonesia and with great excitement decides to join the expedition.

The entire Muppets gang goes on a global tour, selling out grand theaters in some of Europe's most exciting destinations, including Berlin, Madrid, Dublin and London. But mayhem follows the Muppets overseas, as they find themselves unwittingly entangled in an international crime caper headed by Constantine-the World's Number One Criminal and a dead ringer for Kermit the Frog-and his dastardly sidekick Dominic, aka Number Two.